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Innovative Research/Recombinant Equine VEGF-A/IRKFAP0248/25ug

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RecombinantEquineVEGF-A

Thisgeneisamemberoftheplatelet-derivedgrowthfactor(PDGF)/vascularendothelialgrowthfactor(VEGF)familyandencodesaproteinthatisoftenfoundasadisulfidelinkedhomodimer.Thisproteinisaglycosylatedmitogenthatspecificallyactsonendothelialcellsandhasvariouseffects,includingmediatingincreasedvascularpermeABIlity,inducingangiogenesis,vasculogenesisandendothelialcellgrowth,promotingcellmigration,andinhibitingapoptosis.Alternativelysplicedtranscriptvariants,encodingeitherfreelysecretedorcell-associatedisoforms,havebeencharacterized.Asitsnameimplies,VEGF-Aactivityhasbeenstudiedmostlyoncellsofthevascularendothelium,althoughitdoeshaveeffectsonanumberofothercelltypes(e.g.,stimulationmonocyte/macrophagemigration,neurons,cancercells,kidneyepithelialcells).Invitro,VEGF-Ahasbeenshowntostimulateendothelialcellmitogenesisandcellmigration.VEGF-Aisalsoavasodilatorandincreasesmicrovascularpermeabilityandwasoriginallyreferredtoasvascularpermeabilityfactor.

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