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| SPECIES: | Human |
|---|---|
| SOURCESPECIES: | HEK293cells |
| SEQUENCE: | Ala50-Glu254 |
| FUSIONTAG: | FcTag |
| TESTEDAPPLICATIONS: | ELISA,WB |
| APPLICATIONS: | ThisrecombinantproteincanbeusedforE,WB.Forresearchuseonly. |
| BIOLOGICALACTIVITY: | MeasuredbyitsbindingABIlityinafunctionalELISA.ImmobilizedHuman4-1BB,HisTagat100ng/mL(100ul/well),canbindHuman4-1BBLigand,FcTagwithalinearof0.1-2.5ng/mL(Routinelytested). |
| PURITY: | >95%asdeterminedbySDS-PAGE. Endotoxinlevelislessthan1.0EUperugbytheLALmethod. |
|---|---|
| PREDICTEDMOLECULARWEIGHT: | 47.4kDa |
| PHYSICALSTATE: | Lyophilized |
| BUFFER: | 50mMTris,100mMGlycine,pH7.5 |
| STORAGECONDITIONS: | LyophilizedProteinshouldbestoredat-20˚Corlowerforlongtermstorage.Uponreconstitution,workingaliquotsshouldbestoredat-20˚Cor-70˚C.Avoidrepeatedfreeze-thawcycles. |
| ALTERNATENAMES: | 4‑1BBLigand |
|---|---|
| ACCESSIONNO.: | NP_003802 |
| Tumornecrosisfactorligandsuperfamilymember9(4-1BBL)isalsoknownas4-1BBligand,CD137LorTNFSF9,whichisacytokinethatbindstoTNFRSF9.4-1BBListhehighaffinityligandof4-1BB.4-1BBLinducestheproliferationofactivatedperipheralbloodT-cells.Also,4-1BBLmayhavearoleinactivation-inducedcelldeath(AICD).FurThermore,4-1BBLmayplayaroleincognateinteractionsbetweenT-cellsandB-cells/macrophages.Asfordiseases,4-1BBLisinvolvedincancers,infectiousdiseasesandautoimmunediseases. |
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