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Prosci/Activin A Recombinant Protein/91-572/0.05 mg

Specifications

SPECIES:Human
SOURCESPECIES:HumanCells
SEQUENCE:Gly311-Ser426
FUSIONTAG:TagFree
TESTEDAPPLICATIONS:
APPLICATIONS:ThisrecombinantproteincanbeusedforBIOLOGicalassays.Forresearchuseonly.

Properties

PURITY:Greaterthan95%asdeterminedbyreducingSDS-PAGE.
Endotoxinlevellessthan0.1ng/ug(1IEU/ug)asdeterminedbyLALtest.
PREDICTEDMOLECULARWEIGHT:13kD
PHYSICALSTATE:Lyophilized
BUFFER:Lyophilizedfroma0.2umfilteredsolutionofPBS,pH7.4.Itisnotrecommendedtoreconstitutetoaconcentrationlessthan100ug/ml.DissolvethelyophilizedproteininddH2O.
STORAGECONDITIONS:Lyophilizedproteinshouldbestoredat-20˚C,thoughstableatroomtemperaturefor3weeks.
Reconstitutedproteinsolutioncanbestoredat4-7˚Cfor2-7days.
Aliquotsofreconstitutedsamplesarestableat-20˚Cfor3months.

AdditionalInfo

ALTERNATENAMES:InhibinbetaAchain,INHBA,ActivinA
ACCESSIONNO.:P08476

Background

Activinandinhibinaretwocloselyrelatedproteincomplexesthathavealmostdirectlyoppositebiologicaleffects.Activins,membersoftheTGF-betasuperfamily,aredisulfide-linkeddimericproteinsoriginallypurifiedfromgonadalfluidsasproteinsthatstimulatedpituitaryfolliclestimulatinghormone(FSH)release.Inhibins/activinsareinvolvedinregulatinganumberofdiversefunctionssuchashypothalamicandpituitaryhormonesecretion,gonadalhormonesecretion,germcelldevelopmentandmaturation,erythroiddifferentiation,insulinsecretion,nervecellsurvival,embryonicaxialdevelopmentorbonegrowth,dependingontheirsubunitcomposition.Activinsarehomodimersorheterodimersofthevariousbetasubunitisoforms,whileinhibinsareheterodimersofauniquealphasubunitandoneofthevariousbetasubunits.
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