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| SPECIES REACTIVITY: | Human |
|---|---|
| TESTED APPLICATIONS: | Flow, IHC-P, WB |
| APPLICATIONS: | For WB starting dilution is: 1:1000 For IHC-P starting dilution is: 1:50~100 For FACS starting dilution is: 1:10~50 |
| USER NOTE: | Optimal dilutions for each application to be determined by the researcher. |
| PREDICTED MOLECULAR WEIGHT: | 161 kDa |
| IMMUNOGEN: | This ABCC5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 625-652 amino acids from the Central region of human ABCC5. |
| HOST SPECIES: | Rabbit |
| PURIFICATION: | This antibody is purified through a protein A column, followed by peptide affinity purification. |
|---|---|
| PHYSICAL STATE: | Liquid |
| BUFFER: | Supplied in PBS with 0.09% (W/V) sodium azide. |
| CONCENTRATION: | 0.5 mg/ml |
| STORAGE CONDITIONS: | Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| CLONALITY: | Polyclonal |
| ISOTYPE: | Rabbit Ig |
| CONJUGATE: | Unconjugated |
| ALTERNATE NAMES: | Multidrug resistance-associated protein 5, ATP-binding cassette sub-family C member 5, Multi-specific organic anion transporter C, MOAT-C, SMRP, pABC11, ABCC5, MRP5 |
|---|---|
| ACCESSION NO.: | O15440 |
| OFFICIAL SYMBOL: | ABCC5 |
| GENE ID: | 10057 |
| BACKGROUND: | ABCC5 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs,6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. |
|---|---|
| REFERENCES: | 1) Olsen,J.V., et.al., Cell 127 (3), 635-648 (2006) |
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