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| SPECIES: | Human |
|---|---|
| SOURCESPECIES: | E.coli |
| SEQUENCE: | GIINTLQKYYCRVRGGRCAVLSCLPKEEQIGKCSTRGRKCCRRKK |
| TESTEDAPPLICATIONS: |
| PURITY: | Greaterthan98%bySDS-PAGEgelandHPLCanalyses. Endotoxinlevelislessthan0.1ngperμg(1EU/μg). |
|---|---|
| PHYSICALSTATE: | Lyophilized |
| STORAGECONDITIONS: | ThelyophilizedBD3recombinantproteinisstableforatleast2yearsfromdateofreceiptat-20˚C.ReconstitutedBD3isstableforatleast3monthswhenstoredinworkingaliquotswithacarrierproteinat-20˚C.Aswithanyprotein,exposingBD3recombinantproteintorepeatedfreeze/thawcyclesisnotrecommended.Whenworkingwithproteinscareshouldbetakentokeeprecombinantproteinatacoolandstabletemperature. |
| ALTERNATENAMES: | BD-3,HBD3,HBP3,DEFB3,DEFB103,BD3,DEFB103B,Beta-defensin103,Beta-defensin3,BD-3 |
|---|---|
| ACCESSIONNO.: | NP_061131.1 |
| PROTEINGINO.: | 8923890 |
| Defensins(alphaandbeta)arecationicpeptideswithabroadspectrumofantimicrobialactivitythatcompriseanimportantarmoftheinnateimmunesystem.Theα-defensinsaredistinguishedfromtheβ-defensinsbythepairingoftheirthreedisulfidebonds.Todate,fourhumanβ-defensinshavebeenidentified;BD-1,BD-2,BD-3andBD-4.β-defensinsareexpressedonsomeleukocytesandatepithelialsurfaces.Inadditiontotheirdirectantimicrobialactivities,theyarechemoattractanttowardsimmaturedendriticcellsandmemoryTcells.Theβ-defensinproteinsareexpressedastheC-terminalportionofprecursorsandarereleasedbyproteolyticcleavageofasignalsequenceand,inthecaseofBD-1(36a.a.),apropeptideregion.β-defensinscontainasix-cysteinemotifthatformsthreeintra-moleculardisulfidebonds.β-Defensinsare3-5kDapeptidesranginginsizefrom33-47aminoacidresidues.RecombinantHumanBD-3isa5.1kDaproteincontaining45aminoacidresidues. |
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