pNFκBp65 (S536) Antibody BS4138报价/价格抗体 Bioworld 巴傲得生物科技有限公司

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Proteins encoded by the v-Rel viral oncogene and its cellular homolog, c-Rel, are members of a family of transcription factors that include the two subunits of the transcription factor NFκB (p50 and p65) and the Drosophila maternal morphogen, dorsal. Both proteins specifically bind to DNA sequences that are the same or slight variations of the 10 bp kB sequence in the immunoglobulin κ light chain enhancer. This same sequence is also present in a number of other cellular and viral enhancers. The DNA binding activity of NFκB is activated and rapidly transported from the cytoplasm to the nucleus in cells exposed to mitogens or growth factors. CDNAsencodingprecursorsfortwodistinct50kDaproteinshavebeendescribed,designatedp105andp100,respectively.Thep105precursorcontainsp50atitsaminoterminusandaC-terminalregionthatwhenexpressedasaseparatemolecule,designatedPDI,bindstop50andregulatesitsactivity.

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