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Proteins encoded by the v-Rel viral oncogene and its cellular homolog, c-Rel, are members of a family of transcription factors that include the two subunits of the transcription factor NFκB (p50 and p65) and the Drosophila maternal morphogen, dorsal. Both proteins specifically bind to DNA sequences that are the same or slight variations of the 10 bp κB sequence in the immunoglobulin κ light chain enhancer. This same sequence is also present in a number of other cellular and viral enhancers. The DNA binding activity of NFκB is activated and NFκB is subsequently transported from the cytoplasm to the nucleus in cells exposed to mitogens or growth factors. CDNAsencodingprecursorsfortwodistinctproteinshavebeendescribed,designatedp105andp100.Thep105precursorcontainsp50atitsamino-terminusandaC-terminalregionthatwhenexpressedasaseparatemolecule,designatedPDI,bindstop50andregulatesitsactivity.TheNFκBtranscriptionfactorisaproteincomplexconsistingofaDNAbindingsubunitandanassociatedprotein.TheDNAbindingsubunit,alsoreferredtoasRelA,isfunctionallyrelatedtoc-Relp75andRelBp68.NFκBp65isphosphorylatedatSerine276asaresponsetoTNF.蚂蚁淘在线声明：以上所展示的信息由企业自行提供，内容的真实性、准确性和合法性由发布企业负责。蚂蚁淘在线对此不承担任何保证责任。