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Santa Cruz/NGIC-I/sc-222073

NGIC-I

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应用;NGIC-I is a potent, cell-permeable, and selective PKC inhibitor
纯度:≥95%
分子量:364.4
分子式:C23H16N4O
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

NGIC-I is a cell permeable, selective indolocarbazole, which functions as an inhibitor of PKC (protein kinase C). Studies on human CMV (cytomegalovirus) show that UL97 kinases can be inhibited by NGIC-I. As a result of inhibition via NGIC-I on UL 97 kinases, formation of pp65-rich aberrant cytoplasmic tegument aggregate. Studies indicate that protein kinase C is involved in many signal cascades via their function to phosphorylate proteins. The ability to regulate this protein is very useful to control signal transduction cascades. NGIC-I is an inhibitor of cGKI.

参考文献

1. Gershburg, E., et al. 2004. Antimicrob. Agents Chemother. 48: 1900-1903. PMID: 15105156 2. Goldberg, M.D., et al. 2011. J Virol. [Epub ahead of print] . PMID: 21248036

物理状态:
Solid
溶解度:
Soluble in DMSO (5 mg/ml).
保存:
Store at 4° C
IC50:
protein kinase C: IC50 = 75 nM; protein kinase A: IC50 = > 10 µM; protein kinase G: IC50 = 320 nM
仅供科研使用。不可用于诊断或治疗。
PubChem CID:
3714
SMILES:
C1C2=C3C4=CC=CC=C4N(C3=C5C(=C2C(=O)N1)C6=CC=CC=C6N5)CCC#N

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分析证明书

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