NGIC-I is a cell permeable, selective indolocarbazole, which functions as an inhibitor of PKC (protein kinase C). Studies on human CMV (cytomegalovirus) show that UL97 kinases can be inhibited by NGIC-I. As a result of inhibition via NGIC-I on UL 97 kinases, formation of pp65-rich aberrant cytoplasmic tegument aggregate. Studies indicate that protein kinase C is involved in many signal cascades via their function to phosphorylate proteins. The ability to regulate this protein is very useful to control signal transduction cascades. NGIC-I is an inhibitor of cGKI.
1. Gershburg, E., et al. 2004. Antimicrob. Agents Chemother. 48: 1900-1903. PMID: 15105156 2. Goldberg, M.D., et al. 2011. J Virol. [Epub ahead of print] . PMID: 21248036
在PDF文件上阅读,打印和批注,Adobe阅读器是必须的
SouthernBiotech/Goat Anti-Human Lambda-Alexa Fluor® 555/2070-32/1.0 mg
vectorlabs/Biotinylated Aleuria Aurantia Lectin (AAL)/B-1395/1 mg
vectorlabs/VECTASTAIN® Elite® ABC-HRP Kit (Peroxidase, Mouse IgG)/PK-6102/1 kit
vectorlabs/VECTASTAIN® Elite® ABC-HRP Kit (Peroxidase, Universal)/PK-6200/1 kit
vectorlabs/Unconjugated Musa Paradisiaca (Banana) Lectin (BanLec)/L-1410/5 mg
GiottoBiotech/Calmodulin N60D/5 mg/G02CLM60cn