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Santa Cruz/Isovelleral (CAS 37841-91-1)/sc-202669

Isovelleral(CAS37841-91-1)

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备用名:TRPV1 antagonist

应用；Isovelleral is an irritant fungal terpenoid that inhibits the TRPV1 channel

CAS号码:37841-91-1

纯度:≥99%

分子量:232.3

分子式:C₁₅H₂₀O₂

仅供科研使用。不可用于诊断或治疗。

* 参考分析证明大量特定数据 (包括水含量).

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介绍
技术信息
安全信息
安全技术说明书和分析证明书

Isovelleral is an irritant fungal terpenoid that inhibits the TRPV1 (transient receptor potential vanilloid-1) channel. TRPV1 is a Capsaicin receptor that behaves as a non-selective cation channel that is mainly found in the sensory neurons, and specifically detects painful stimuli, low pH and heat. Research shows that out of twenty unsaturated sesquiterpene dialdehydes tested for cytotoxic and antimicrobial activity, Isovelleral was one of the most potent compounds. The compound has been shown to activate the ion channel, TRPA1, which is associated in the signaling of inflammatory pain. Isovelleral is an inhibitor of VR1 and an activator of ANKTM1.

参考文献

1. Anke, H. and Sterner, O. 1999. Planta Med. 57: 344-346. PMID: 1775575 2. Jonassohn, M., et al. 1997. Bioorg. Med. Chem. 5: 1363-1367. PMID: 9377096 3. Ralevic, V., et al. 2003. Biochem. Pharmacol. 65: 143-151. PMID: 12473388 4. Escalera, J., et al. 2008. J. Biol. Chem. 283: 24136-24144. PMID: 18550530 5. Schumacher, M.A. and Eilers, H. 2010. Front. Biosci. 15: 872-882. PMID: 20515731

外观:

Crystalline

物理状态:

Solid

溶解度:

Soluble in organic solvents. Insoluble in water.

保存:

Store at -20° C

熔点:

101.85° C (Predicted)

沸点:

322.79° C at 760 mmHg (Predicted)

密度:

1.21 g/cm³ (Predicted)

折射率:

n²⁰_D 1.64 (Predicted)

IC50:

EDG-6: IC₅₀ = 253 nM (human); GPR55: IC₅₀ = 500 nM (human); Heat shock factor protein 1: IC₅₀ = 530 nM (mouse); XBP-1: IC₅₀ = 2.35 µM (human); EDG-1: IC₅₀ = 4.96 µM (human)

仅供科研使用。不可用于诊断或治疗。

德国水公害等级:

RTECS:

GZ2245000

PubChem CID:

37839

MDL 号码:

MFCD01735881

Beilstein 注册:

2506661

SMILES:

C[[email protected]]12C[[email protected]]1(C(=C[[email protected]]3[[email protected]@H]2CC(C3)(C)C)C=O)C=O

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