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Santa Cruz/Reveromycin A (CAS 134615-37-5)/sc-202314

Reveromycin A(CAS134615-37-5)

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应用；Reveromycin A is a spiroketal antibiotic inhibitor of EGF mitogenic activity

CAS号码:134615-37-5

纯度:>99%

分子量:660.8

分子式:C₃₆H₅₂O₁₁

仅供科研使用。不可用于诊断或治疗。

* 参考分析证明大量特定数据 (包括水含量).

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介绍
技术信息
安全信息
安全技术说明书和分析证明书

Reveromycin A, the dominant analogue of a complex of spiroketals isolated from a Streptomyces sp., is an inhibitor of the mitogenic activity of EGF (epidermal growth factor). It is a G1 phase cell cycle inhibitor, selectively inhibiting IleRS (isoleucyl-tRNA synthetase). Reveromycin A displays antiproliferative behaviour against human cell lines KB and K562, as well as potent antifungal activity. More recently it has been shown to induce apoptosis in osteoclasts thus inhibiting bone resorption.

参考文献

1. Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts. Woo J.T. et al. Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 4729. 2. Reveromycin A inhibits osteolytic bone metastasis of small-cell lung cancer cells, SBC-5, through an antiosteoclastic activity. Muguruma H. et al. Clin. Cancer Res. 2005, 11, 8822. 3. Identification of Saccharomyces cerevisiae isoleucyl-tRNA synthetase as a target of the G1-specific inhibitor Reveromycin A. Miyamoto Y. et al. J. Biol. Chem. 2002, 277, 28810. 4. Reveromycins, new inhibitors of eukaryotic cell growth. II. Biological activities. Takahashi H. et al. J. Antibiot. 1992, 45, 1414.

外观:

Lyophilized

物理状态:

Solid

来源于:

Streptomyces sp.

溶解度:

Soluble in ethyl acetate, ethanol, methanol, DMF, and DMSO.

保存:

Store at -20° C

沸点:

849.02° C at 760 mmHg (Predicted)

密度:

1.22 g/cm³ (Predicted)

折射率:

n²⁰_D 1.56 (Predicted)

IC50:

IleRS: IC₅₀ = 1.97 nM (rat); IleRS: IC₅₀ = 4.46 nM (human); NRK: EC₅₀50 = 2.39 µM (rat)

pK值:

pK_a: 4.36 (Predicted)

仅供科研使用。不可用于诊断或治疗。

德国水公害等级:

PubChem CID:

9939559

MDL 号码:

MFCD00912537

SMILES:

CCCCC1(CCC2(CCC(C(O2)CC=C(C)C=CC(C(C)C=CC(=O)O)O)C)OC1C=CC(=CC(=O)O)C)OC(=O)CCC(=O)O

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PMID: # 18840695Yano, A. et al. 2008. Proc. Natl. Acad. Sci. U.S.A. 105: 15541-15546.