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Santa Cruz/YM 298198 hydrochloride (CAS 748758-45-4)/sc-361412

YM 298198 hydrochloride(CAS748758-45-4)

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备用名:6-Amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide hydrochloride
应用；YM 298198 hydrochloride is a selective noncompetitive antagonist of mGluR-1
CAS号码:748758-45-4
分子量:378.92
分子式:C18H22N4OS•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

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YM 298198 hydrochloride has been shown to be a noncompetitive antagonist selective for mGluR-1. This compound also displays the ability to inhibit glutamate-induced IP production more potently than CPCCOEt.

物理状态:
Solid
溶解度:
Soluble in water (5 mg/ml).
保存:
Desiccate at 4° C
折射率:
n20D 1.73 (Predicted)
IC50:
Glutamate-induced inositol phosphate production: IC50 = 16 nM (NIH3T3 cells); mGlu2,3,4,5,6,, and 7 and ionotropic receptors: IC50 = > 10 µM
Ki 数据:
mGlu1 receptors : Ki= 19 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
德国水公害等级:
3
PubChem CID:
45073464
MDL 号码:
MFCD08703122
SMILES:
CC1=C(SC2=NC3=C(N12)C=C(C=C3)N)C(=O)N(C)C4CCCCC4.Cl

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