AC 45594 is a selective inverse agonist at the orphan nuclear receptor SF-1 (steroidogenic factor-1) (IC50= 50-100 nM). Displays no activity at estrogen, LRH-1, ROR, ERR or Nurr receptors. Inhibits SFRE-mediated transcription.
Del Tredici et al (2008) Identification of the first synthetic steroidogenic factor 1 inverse agonist.: pharmacological modulation of steroidogenic enymes. Mol.Pharmacol. 73 900.
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