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Xcessbio/A-366, G9a/GLP HMTase Inhibitor-Xcessbio Biosciences Inc/2 mg solid/M60210-2s188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Xcessbio/A-366, G9a/GLP HMTase Inhibitor-Xcessbio Biosciences Inc/2 mg solid/M60210-2s

Details
ProductInformation
Storage:Powder:4oC1year.DMSO:4oC3month;-20oC1year.
Purity:≥98%
CAS#:1527503-11-2
Solubility:DMSOupto100mM
ChemicalName:5"-methoxy-6"-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3"-indol]-2"-amine
MolecularWeight:329.44
Formula:C19H27N3O2

BIOLOGicalActivity:

A-366isanovelhighlypotent,selectiveandcellpermeableG9a/GLPhistonelysinemethyltransferaseinhibitorwithanIC50~3.3nM.Ithasselectivity>1000-foldover21othermethyltransferases.A-366hasbeenshowntoinhibitH3K9methylationinprostatecancerPC3cellswithanIC50of100nMandexhibitsminimalcellulartoxicitycomparedwithpreviousquinazoline-basedprobes,suchasBIX-01294andUNC0638.

HowtoUse:

Invitro:A-366wasusedat1µMinvitroandcellularassays.

Invivo:n/a

Reference:

  1. 1.SweisRF,etal.Discoveryanddevelopmentofpotentandselectiveinhibitorsofhistonemethyltransferaseg9a.(2014)ACSMedChemLett.5(2):205-9.
  2. 2.http://www.thesgc.org/chemical-probes/A-366
A-366_spec.pdf
A-366_MSDS.pdf
Productsareforresearchuseonly.Notforhumanuse.

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