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| Molecular Weight: | 308.65 |
| Formula: | C12H6ClFN4O3 |
| Purity: | ≥98% |
| CAS#: | 1422955-31-4 |
| Solubility: | DMSO up to 50 mM |
| Chemical Name: | N-(3-chloro-5-fluorophenyl)-4-nitrobenzo[c][1,2,5]oxadiazol-5-amine |
| Storage: | Powder:4oC 1 year. DMSO:4oC3 month;-20oC 1 year. |
Biological Activity:
HIF-C2 is a potent and selective allostericinhibitor of hypoxia inducible factor-2 (HIF-2). It binds within the internalcavity of HIF-2α PAS-B (Kd of 81 nM) and disrupts heterodimerizationof the full-length HIF-2 transcription factor. HIF-C2 functions effectively as aHIF-2 inhibitor in living cells, disrupting HIF-2 DNA binding and inhibiting thetranscription of its target genes. Moreover, HIF-C2 is selective for the HIF-2isoform and has no activity to antagonize HIF-1. HIF-C2 provides an opportunityto delineate differences in HIF-1 and HIF-2 biology and serves as an entrypoint for development of HIF-2 inhibitor drugs for treating diseases, includingrenal cell carcinomas.
How to Use:
Reference:
HIF-C2_spec.pdfHIF-C2_MSDS.pdfProducts are for research use only. Not for human use.
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