MolecularWeight: | 669.80 |
Formula: | C35H49F2N7O4 |
Purity: | ≥98% |
CAS#: | 1417329-24-8 |
Solubility: | DMSOupto100mM |
ChemicalName: | (S)-N-(bis(4-fluorophenyl)methyl)-1-(2-(2-ethyl-2-isobutyramidobutanamido)-5-guanidinopentanamido)cyclopentanecarboxamide |
Storage: | Powder:4oC1year.DMSO:4oC3month;-20oC1year. |
BIOLOGicalActivity:
MM-102isahighlypotentandselectiveinhibitoroftheMLL1/WDR5interactionwithanIC50~2.9nMbindingaffinitytoWDR5.IntheMLL1-AF9transducedmurinecells,MM-102specificallyreducesexpressionoftwocriticalMLL1targetgenes(HoxA9andMeis-1),whicharerequiredforMLL1mediatedleukemogenesis.MM-102alsospecificallyinhibitscellgrowthandinducesapoptosisinleukemiacellsharboringMLL1fusionproteins.MM-102providesthefirstproof-of-conceptsmallmoleculeinhibitortotargettheWDR5/MLL1protein-proteininteractionasanoveltherapeuticapproachforacuteleukemiaharboringMLL1fusionproteins.
HowtoUse:
Reference:
Productsareforresearchuseonly.Notforhumanuse.
SouthernBiotech/Goat Anti-Human Lambda-Alexa Fluor® 555/2070-32/1.0 mg
vectorlabs/Biotinylated Aleuria Aurantia Lectin (AAL)/B-1395/1 mg
vectorlabs/VECTASTAIN® Elite® ABC-HRP Kit (Peroxidase, Mouse IgG)/PK-6102/1 kit
vectorlabs/VECTASTAIN® Elite® ABC-HRP Kit (Peroxidase, Universal)/PK-6200/1 kit
vectorlabs/Unconjugated Musa Paradisiaca (Banana) Lectin (BanLec)/L-1410/5 mg
GiottoBiotech/Calmodulin N60D/5 mg/G02CLM60cn