Chemical Name: | (E)-1-(4-(1-(((4-cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-ethylbenzyl)azetidine-3-carboxylic acid |
Molecular Weight: | 516.60 |
Formula: | C29H35F3N2O3 |
Purity: | ≥ 98% |
CAS#: | 800379-64-0 |
Solubility: | DMSO up to 100 mM |
Storage: | Powder:4oC 1 year DMSO:4oC3 month-20oC 1 year |
BAF312 is a next-generation potent sphingosine 1-phosphate (S1P) receptor agonist, selective for S1P1 (EC50 ~0.39 nM) and S1P5 (EC50 ~0.98 nM). As S1P1 plays a central role in lymphocyte egress from lymph nodes and is a validated drug target in immune-mediated diseases, BAF312 is currently in clinical trials to treat multiple sclerosis.
How to Use:
In vitro: BAF312 was used at 0.1µM in vitro.
In vivo: BAF312 was orally dosed once daily at 0.3-3 mg/kg in chronic EAE, DA rats and was shown good efficacy.
Reference:
BAF312_spec.pdf
BAF312_MSDS.pdf
Products are for research use only. Not for human use.
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