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| Molecular Weight: | 420.52 |
| Formula: | C24H24N2O3S |
| Purity: | ≥98% |
| CAS#: | n/a |
| Solubility: | DMSO up to 50 mM |
| Chemical Name: | 3-(benzo[d]thiazol-2-yl)-6-ethyl-7-hydroxy-8-(piperidin-1-ylmethyl)-4H-chromen-4-one |
| Storage: | Powder:4oC 1 year. DMSO:4oC3 month;-20oC 1 year. |
Biological Activity:
SKP2-C25 is a potent, selective and cell permeable Skp2 inhibitor. It selectively inhibits Skp2 E3 ligase activity, but not activity of other SCF complexes. It also phenocopies the effects observed upon genetic Skp2 deficiency, such as suppressing survival and Akt-mediated glycolysis and triggering p53-independent cellular senescence. SKP2-C25 exhibits potent antitumor activities in multiple animal models and cooperates with chemotherapeutic agents to reduce cancer cell survival. It is a useful chemical probe to target Skp2, which is a promising target for restricting cancer stem cell and cancer progression.
How to Use:
Reference:
SKP2-C25_spec.pdfSKP2-C25_MSDS.pdf
Products are for research use only. Not for human use.
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