Cellsthatmakeuptissuesandorgansaresituatedwithinacomplex3Dstructureknownastheextracellularmatrix.Despitethisahighproportionofthecurrentresearchbeingundertakenonthesecellsisbeingperformedusing2Dcultures.Theshapeandsizeofacellisaffectedbythephysicalenvironmentinwhichitisgrown.3Dcellculturesaimtoprovideacloserrepresentationofacellsnaturalenvironment.
Belowisacomparisonofthebenefitsanddisadvantagesofboth3Dand2Dcellcultures.Hoverovereachbulletpointtolearnmoreaboutthatparticularadvantage.
Pleaseclickonthelinksontheleftofthispagetolearnmoreabouteither2Dor3Dcellcultures.
Belowaresomepeer-reviewedpapersthathaveused3Dcellcultures.Clickonthenameofthepapertobetakentoit.
Ratprimaryhepatocytesshowenhancedperformanceandsensitivitytoacetaminophenduringthree-dimensionalcultureonapolystyrenescaffolddesignedforroutineuse.
Schutte,M.,Fox.B.,Baradez,M.,Devonshire,A.,Minguez.,J.,Bokhari.M.,Przyborski.S.,Marshall.D.,(2011)
AssayandDrugDevelopmentTechnologies
DOI:10.1089/adt.2011.0371
Adiposetissue-derivedstemcellsdisplayaproangiogenicphenotypeon3Dscaffolds.
Neofytou.E.A.,Chang.E.,Patlola.B.,Joubert.L.M.,Rajadas.J.,Gambhir.S.S.,Cheng.Z.,Robbins.R.C.,Beygui.R.E.,(2011)
JournalBiomedicalMaterialsResearchPartA
DOI:10.1002/jbm.a.33113
DysregulatedTRKsignallingisatherapeutictargetinCYLDdefectivetumours.
Rajan.N.,Elliott.R.,Clewes.O.,Mackay.A.,Reis-Filho.J.S.,Burn.J.,Langtry.J.,Sieber-Blum.M.,Lord.C.J.,Ashworth.A.,(2011)
Oncogene
DOI:10.1038/onc.2011.133
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