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Cellagentech/ABT378 (Lopinavir) | HIV1 protease inhibitor/C237810/10 mg (powder)188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Cellagentech/ABT378 (Lopinavir) | HIV1 protease inhibitor/C237810/10 mg (powder)
ProductDescription

Lopinavir(ABT-378),designedinresponsetoVal82mutantstrainsofHIV[1],isapotentinhibitorofHIVproteasewithKiof1.3-3.6pM.LopinavirinhibitsreplicationofHIV-1withanEC50of6-17nM.[2]

RitonavirwasfoundtoinhibitthemetabolismoflopinavirwithnootherantagoNISTiceffects;thereforelopinavirsdrugexposurecanbeenhancedbyco-formulationwithritonavir.Inthepresenceof50%humanserum,themeanEC50oflopinavirforfivelaboratoryHIV-1isolatesrangedfrom65to289nM.[3]

Technicalinformation:

ChemicalFormula: C37H48N4O5
CAS#: 192725-17-0
MolecularWeight: 628.8
Purity: >98%
Appearance: White
ChemicalName: (S)-N-((2S,4S,5S)-5-(2-(2,6-dimethylphenoxy)acetamido)-4-hydroxy-1,6-diphenylhexan-
2-yl)-3-methyl-2-(2-oxo-tetrahydropyrimidin-1(2H)-yl)butanamide
Solubility: Upto100mMinDMSO
Synonyms: ABT-378,ABT378,Lopinavir

ShippingCondition:Theproductisshippedinaglassvialatambienttemperature.
Storagecondition:Forlongershelflife,storesolidpowderat4oCdesiccated,orstoreDMSOsolutionat-20oC.

Reference:

1.Stolletal.,X-rayCrystallographicStructureofABT-378(Lopinavir)BoudntoHIV-1Protease.Bioorg.Med.Chem.2002,10,2803-2806.PubmedID:12057670
2.Shametal.,ABT-378,aHighlyPotentInhibitoroftheHumanImmunodeficiencyVirusProtease.Antimicrob.AgentsChemother.1998,42(12),3218-3224.PubmedID:9835517
3.Qazietal.,Lopinavir/ritonavir(ABT-378/r).ExpertOpin.Pharmacother.2002,3(2),315-327.


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