企业QQ
官方微信
ThismonoclonalantibodyenablessensitiveandspecificdetectionofhumanIL-17Aproducingcellsinflowcytometry.Itissuppliedasaready-to-usesolutionofFITC-conjugatedmAbMT504.
MT504isalsoavailablebiotinylated.SeeRelatedproducts.
Themonoclonalantibodycross-reactswithIL-17Afromnon-humanprimates.SeetheHuman/NHPcross-reactivitytable.
Theantibodyalsocross-reactswithIL-17Afromcow,sheep,horse,piganddog.SeetheVeterinarytable
IL-17A
Interleukin-17A(IL-17A,IL17A)isapotentproinflammatorycytokineproducedbyactivatedTh17(T-helper17)cellsandcertaincellsbelongingtotheinnateimmunesystem.Inmice,IL-17hasbeenshowntoalsobeproducedbyactivatedCD8+TcellsandγδTcells.Th17cellsplayanimportantroleinautoimmunediseasesandprotectionagainstbacteriaandfungi.IL-17Aactsonabroadrangeofcelltypestoinduceexpressionofcytokines,chemokinesandmetalloproteinases.Asaresult,secretionofIL-17Apromotesinflammatoryresponses,whichleadstotherecruitmentofneutrophils,enhancementofantibodyproductionandactivationofTcells.IncreasedexpressionofIL-17Aisseeninautoimmunediseasessuchasmultiplesclerosisandrheumatoidarthritis.Itisalsoassociatedwithasthma,psoriasis,cancerandtransplantrejection.
| Application: |
|
|---|---|
| Reactivity: |
|
| Format: | Fluorophore-conjugated |
| Specificity: | NativeandrecombinantIL-17A. |
| Isotype: | MouseIgG1 |
| Contents: |
|
| Size: | 100tests |
| Otherformats: | ClicktoviewallCow/Dog/Horse/Human/NHP/Pig/SheepIL-17Aproducts |