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BioXcell/InVivoMAb anti-human CD19/AMOUNT GREATER THAN 100 MG: (QUOTE ONLY)/BE0281-CUST

AboutInVivoMAbanti-humanCD19

The4G7monoclonalantibodyreactswithhumanCD19,aBcell-specific95kDatransmembraneglycoproteinoftheimmunoglobulinsuperfamily.CD19containstwoextracellularimmunoglobulin-likedomainsandanextensivecytoplasmictail.ItfunctionsasapositiveregulatorofB-cellreceptorsignalinginconjunctionwithCD21andCD81.CD19ishighlyexpressedinmostlymphomasandleukemiasincludingsomeearlyB-cellmalignanciesthatdonotexpressCD20.ForthesereasonsCD19isquicklybecominganattractivealternativetargetfortheimmunotherapyoflymphoproliferativedisorders.

InVivoMAbanti-humanCD19Specifications

Isotype

MouseIgG1

RecommendedIsotypeControl(s)InVivoMAbmouseIgG1isotypecontrol,unknownspecificity(BE0083)
RecommendedInVivoPureDilutionBufferInVivoPurepH7.0DilutionBuffer(IP0070)
Immunogen

Humanchroniclymphocyticleukemia(CLL)cells

ReportedApplications
  • Flowcytometry
  • Functionalassays
  • Immunofluorescence
  • Chimericantigenreceptorconstruction(see Poirot,L.,etal.reference)
Endotoxin
  • <2EU/mg(<0.002EU/μg)
  • DeterminedbyLALgelclottingassay
Purity
  • >95%
  • DeterminedbySDS-PAGE
Formulation
  • PBS,pH7.0
  • ContainsnostABIlizersorpreservatives
Sterility

0.2μMfiltered

Production

Purifiedfromtissueculturesupernatantinananimalfreefacility

Purification

ProteinG

Storage

Theantibodysolutionshouldbestoredatthestockconcentrationat4°C.Donotfreeze.

RRID

AB_2687804

MolecularWeight

150kDa

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