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BioXcell/InVivoMAb anti-mouse CD38/REGULAR 1MG/BE0317-R001mg

AboutInVivoMAbanti-mouseIL-12p40

TheC17.8antibodyreactswithmousep40alsoknownasIL-12β.p40isa40kDasubunitofIL-12andIL-23.IL-12isaheterodimericcytokinecomposedofsubunitsIL-12αp35andIL-12βp40.Thep40subunitofIL-12alsocombineswithp19,aproteinthatshowsnoBIOLOGicalactivitybyitself,toformIL-23.IL-12issecretedbyactivatedmonocytes,macrophages,anddendriticcellswhileIL-23issecretedbyactivateddendriticcellsandepithelialcells.IL-12playsrolesinTlymphocytedifferentiation,IFNγproduction,andNKcellcytotoxicity.TheC17.8antibodyhasbeenshowntoneutralizebothIL-12andIL-23bioactivity.

InVivoMAbanti-mouseIL-12p40Specifications

Isotype

RatIgG2a, κ

RecommendedIsotypeControl(s)InVivoMAbratIgG2aisotypecontrol,anti-trinitrophenol(BE0089)
RecommendedInVivoPureDilutionBufferInVivoPurepH7.0DilutionBuffer(IP0070)
Immunogen

RecombinantmouseIL-12p70

ReportedApplications
  • invivoIL-12p40neutralization
  • p40affinitychromatography
  • Immunoprecipitation
  • ELISA
  • Flowcytometry
  • Westernblot
Endotoxin
  • <2EU/mg(<0.002EU/μg)
  • DeterminedbyLALgelclottingassay
Purity
  • >95%
  • DeterminedbySDS-PAGE
Formulation
  • PBS,pH7.0
  • ContainsnostABIlizersorpreservatives
Sterility

0.2μMfiltered

Production

Purifiedfromtissueculturesupernatantinananimalfreefacility

Purification

ProteinG

Storage

Theantibodysolutionshouldbestoredatthestockconcentrationat4°C.Donotfreeze.

RRID

AB_1107698

MolecularWeight

150kDa

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