The YIGIF74-1G7 monoclonal antibody reacts with mouse IL-18, an 18 kDa pro-inflammatory cytokine. IL-18 is expressed by activated macrophages, keratinocytes, Kupffer cells, intestinal epithelial cells, and osteoblasts. IL-18 has been shown to activate NF-κB, induce Fas ligand expression, induce both CC and CXC chemokine expression, and enhance the production of IFNγ and GM-CSF.
Isotype | Rat IgG2a, κ |
Recommended Isotype Control(s) | InVivoMAb rat IgG2a isotype control, anti-trinitrophenol(BE0089) |
Recommended InVivoPure Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer(IP0070) |
Immunogen | Not available or unknown |
Reported Applications | in vivo IL-18 neutralization |
Endotoxin |
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Purity |
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Formulation |
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Sterility | 0.2 μM filtered |
Production | Purified from tissue culture supernatant in an animal free facility |
Purification | Protein G |
Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
RRID | AB_2687719 |
Molecular Weight | 150 kDa |
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