rPeptide/Tau1A6 Antibody Kit TA2004/TA11042/100ug

Tauisafamilyofsixisoforms,derivedfromasinglegenebyalternativemRNAsplicing¹.Theyvaryinsizefrom352to441aminoacids(36.8to45.9kDa),anddifferfromoneanotherinhavingthreeorfourmicrotubulebindingrepeats(R)of31-32aminoacidseach,andtwo,oneornoneaminoterminalinserts(N)of29aminoacidseach².

Taupromotestheassemblyandmaintainsthestructureofmicrotubulesinneuronalcells^3,4,5.Whilethefetalbraincontainsasingleisoformoftau(Tau-352)theadultbrainhasseveralisoforms.TauisbothphosphorylatedandO-GlcNAcylated⁶.Thenormalbraintaucontains2-3molesofphosphate/moleoftheprotein.InAlzheimerdiseasetauishyperphosphorylated,containing3-4-foldmorephosphate/moleoftheproteinthanthenormaltau^7,8andisthemajorproteinsubunitofpairedhelicalfilaments(PHF)thatformtheneurofibrillarytangles(NFT).NFTaccumulationcorrelateswiththeclinicalprogressionofAlzheimersdisease.Tau-1A6(TA-1002;PatentPending)isaproprietaryrPeptideTauMonoclonalAntibodythatbindsall6Tauisoforms.