rPeptide/Tau4G11 Antibody Kit/TA11111/50ug

Tauisafamilyofsixisoforms,derivedfromasinglegenebyalternativemRNAsplicing¹.Theyvaryinsizefrom352to441aminoacids(36.8to45.9kDa),anddifferfromoneanotherinhavingthreeorfourmicrotubulebindingrepeats(R)of31-32aminoacidseach,andtwo,oneornoneaminoterminalinserts(N)of29aminoacidseach².

Taupromotestheassemblyandmaintainsthestructureofmicrotubulesinneuronalcells^3,4,5.Whilethefetalbraincontainsasingleisoformoftau(Tau-352)theadultbrainhasseveralisoforms.TauisbothphosphorylatedandO-GlcNAcylated⁶.Thenormalbraintaucontains2-3molesofphosphate/moleoftheprotein.InAlzheimerdiseasetauishyperphosphorylated,containing3-4-foldmorephosphate/moleoftheproteinthanthenormaltau^7,8andisthemajorproteinsubunitofpairedhelicalfilaments(PHF)thatformtheneurofibrillarytangles(NFT).NFTaccumulationcorrelateswiththeclinicalprogressionofAlzheimersdisease.Tau4G11(TA-1001)isarPeptideexclusiveTauMonoclonalAntibodythatbinds4outofthe6Tauisoforms.ItspecificallybindsTau-381,Tau-410,Tau-412,andTau-441whichallcontainatleastoneaminoterminalinsert.