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CatalogNo.:AB0070-100
Price/Unit:EUR320.00
Source:Goat
Quantity/unitsize:300µg
Description:Goatpolyclonaltoalphasubunitoftranscriptionfactorhypoxia-inducIBLefactor-1(HIF-1),whichisaheterodimercomposedofanalphaandabetasubunit.HIF-1functionsasamasterregulatorofcellularandsystemichomeostaticresponsetohypoxiabyactivatingtranscriptionofmanygenes,includingthoseinvolvedinapoptosis,angiogenesis,energymetabolism,andothergeneswhoseproteinproductsincreaseoxygendeliveryorfacilitatemetabolicadaptationtohypoxia.HIF-1thusplaysanessentialroleintumourangiogenesis,embryonicvascularization,andpathophysiologyofischemicdisease.Alternativenames:alphasubunit(basichelix-loop-helixtranscriptionfactor),ARNTinteractingprotein,basic-helix-loop-helix-PASproteinMOP1,bHLHe78,classEbasichelix-loop-helixprotein78,HIF-1alpha,HIF1,HIF1-ALPHA,HIF1a,hypoxiainduciblefactor1,hypoxia-induciblefactor1alphaisoformI.3,hypoxia-induciblefactor1,hypoxia-induciblefactor1-alpha,memberofPASprotein1,memberofPASsuperfamily1,MOP1,PASD8,PASdomain-containingprotein8antibody.
Form:Polyclonalantibodysuppliedasa100µl(3mg/ml)aliquotinPBS,20%glyceroland0.05%sodiumazide.Thisantibodyisepitope-affinitypurifiedfromgoatantiserum.
Immunogen:Recombinantpeptidederivedfromwithinresidues470to590aaofhumanHIF1aproducedinE.coli.
Specificity:DetectsHIF1aintransfectedcellsandabandofapproximately120kDabyWesternblotincelllysates.
Reactivity:Reactsagainsthuman,canineandmouseproteins.
Usage:Westernblot 1:500-1:2,000Immunofluorescence NDImmunohistochemistry(paraffin) NDImmunohistochemistry(frozen) ND
Reactivitychart
| Sample | WesternBlot | Immuno-fluorescence | Immuno-Histochemistry(p) | Immuno-Histochemistry(f) | human | +++ | ND | ND | ND | rat | +++ | ND | ND | ND | mouse | +++ | ND | ND | ND | canine | +++ | ND | ND | ND | monkey | +++ | ND | ND | ND |
|---|
Storage:Storeat-20Cforlong-termstorage.Storeat2-8Cforuptoonemonth.
Specialinstructions:Avoidfreeze/thawcycles.
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