Fitzgerald/TARDBP antibody/10R1095/100 ul

OVERVIEW:

Synonyms	Monoclonal TARDBP antibody, Anti-TARDBP antibody, TDP-43 antibody, TAR DNA binding protein antibody, TAR DNA binding protein antibody, ALS10 antibody, TAR DNA-binding protein 43 antibody, ALS10 antibody, TDP-43 antibody, TAR DNA-binding protein 43 antibody, TDP43 antibody, Anti TARDBP antibody , TARDBP antibody, TDP43 antibody
Specificity	Human
Cross Reactivity	To be determined by end-user.
Applications	ELISA, IHC, WB
Immunogen	TARDBP antibody was raised in mouse using recombinant human TARDBP (1-260aa) purified from E. coli as the immunogen.

SPECIFICATIONS:

Host	Mouse
Clone	k1B8
Isotype	IgG1 kappa
Source	Anti-human TARDBP antibody, clone k1B8, is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human TARDBP protein.
Method of Purification	TARDBP antibody was purified by protein-G affinity chromatography
Form & Buffer	Supplied as a liquid in PBS, pH 7.4, with 0.1% NaN3.
Concentration	1 mg/ml

STORAGE & SAFETY:

Storage	Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

Usage Assay Information:

Usage Recommendations	WB: 1:1,000-1:2,000

GENERAL INFORMATION:

Biological Significance	TAR DNA binding protein (TARDBP), also known as TDP-43, is a cellular protein. TARDBP was identified as the disease accumulating protein in patients with frontotemporal lobar degeneration (FTLD) with ubiquitin inclusions (FTLD-U) and in amyotrophic lateral sclerosis (ALS). TARDBP functions as a DNA-binding protein and specifically binds to the TAR DNA sequence motifs of HIV. Via this association with TAR motifs, TARDBP acts as a transcriptional repressor and inhibits HIV-1 transcription. In addition, this protein regulates alternate splicing of the cystic fibrosis transmembrane receptor (CFTR) gene.

Biological Significance

TAR DNA binding protein (TARDBP), also known as TDP-43, is a cellular protein. TARDBP was identified as the disease accumulating protein in patients with frontotemporal lobar degeneration (FTLD) with ubiquitin inclusions (FTLD-U) and in amyotrophic lateral sclerosis (ALS). TARDBP functions as a DNA-binding protein and specifically binds to the TAR DNA sequence motifs of HIV. Via this association with TAR motifs, TARDBP acts as a transcriptional repressor and inhibits HIV-1 transcription. In addition, this protein regulates alternate splicing of the cystic fibrosis transmembrane receptor (CFTR) gene.

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