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| Synonyms | MonoclonalBCL3antibody,Anti-BCL3antibody,BCL-3antibody,BCL3,BCL4antibody,BCL-3,D19S37antibody,B-celllymphoma3encodedproteinantibody,BCL3,BCL3antibody |
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| Specificity | HumanBCL3 |
| CrossReactivity | Human,Mouse,Rat.Otherspeciesnotstudied |
| Applications | DotBlot,ICC,WB |
| Immunogen | BCL3antibodywasraisedinmouseusingrecombinantHumanB-CellCll/Lymphoma3(Bcl3) |
| Host | Mouse |
|---|---|
| Clone | 2069E2a |
| Isotype | IgG1 |
| MethodofPurification | BCL3antibodywaspurifiedusingproteinGcolumnchromatographyfromculturesupernatantofhybridomaculturedinamediumcontainingbovineIgG-depleted(approximately95%)fetalbovineserum. |
| Form&Buffer | BCL3antibodyinPBS(3.0mMKCl,1.5mMKH2PO4,140mMNaCl,8.0mMNa2HPO4(pH7.4))containing1%bovineserumalbumin(BSA)and0.05%sodiumazide(NaN3). |
| Concentration | 100ug/ml |
| Storage | Storeat2-8degCforuptooneyear.Werecommendlongtermstorageat-20degC.Avoidrepeatedfreezingandthawing. |
|---|---|
| BiohazardInformation | Thisantibodysolutioncontainssodiumazide(NaN)asapreservative.ThereisapotentialhazardthatNaNreactswithcopperorleadtoproduceanexplosivecompound.Forsafedisposal,thevialhastobewashedthoroughlywithwater.Itisstronglyadv |
| UsageRecommendations | WB:0.2-2ug/ml |
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| BiologicalSignificance | Thisgeneisaproto-oncogenecandidate.Itisidentifiedbyitstranslocationintotheimmunoglobulinalpha-locusinsomecasesofB-cellleukemia.Theproteinencodedbythisgenecontainssevenankyrinrepeats,whicharemostcloselyrelatedtothosefoundinIkappaBproteins.Thisproteinfunctionsasatranscriptionalco-activatorthatactivatesthroughitsassociationwithNF-kappaBhomodimers.TheexpressionofthisgenecanbeinducedbyNF-kappaB,whichformsapartoftheautoregulatoryloopthatcontrolsthenuclearresidenceofp50NF-kappaB. |
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