Human MFGE8/Lactadherin ELISA Kit

货号：	IRKTAH5179
供应商：	上海钰博生物科技有限公司
数量：	大量
英文名：	HumanMFGE8/LactadherinELISAKit
保质期：	1年
保存条件：	-2-8℃
规格：	盒

HumanMFGE8/LactadherinELISAKit

ProductDescription

HumanMFGE8/LactadherinELISAKit-1Kit(96Wells)

OurHumanMFGE8/LactadherinELISAKitisasandwichELISAintendedforthequantitativedeterminationofhumanMFGE8incellculturesupernates,serum,plasma(heparin,EDTA),saliva,urineandhumanmilk.

MFGE8(MilkFatGlobule-EgfFactor8),alsocalledasLactadherinorSED1,isaproteinwhichinhumansisencodedbytheMFGE8gene.Mfge8issecretedproteinfoundinvertebrates,includingmammalsaswellasbirds.Byfluorescenceinsituhybridization,theMFGE8genewasmappedtochromosome15q25.MFGE8isafactorthatlinksapoptoticcellstophagocytes.Itspecificallyboundtoapoptoticcellsbyrecognizingaminophospholipidssuchasphosphatidylserine.MFGE8,whenengagedbyphospholipids,boundtocellsviaitsRGDmotif.Itboundparticularlystronglytocellsexpressingalpha-V-beta-3integrin.ItshowedthatMfge8wasexpressedinintestinallaminapropriamacrophagesinmice.Usingawound-healingassay,theyshowedthatMfge8promotedmigrationofintestinalepithelialcellsthroughaPKC-epsilon(PRKCE)-dependentmechanism.

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