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reprocell/Stemolecule DAPT/04-0041-base

Stemolecule DAPT (also known as GSI-IX or LY-374973), a cell-permeable dipeptide, inhibits γ-secretase and indirectly inhibits Notch, a γ-secretase substrate1. Since the Notch pathway is involved in the development of both the nervous system and pancreas, DAPT may be useful in modulating Notch activity in embryonic stem cell differentiation studies2. DAPT has been shown to dose-dependently decrease amyloidβ levels via inhibition of γ-secretase in both plasma and cerebral spinal fluid3. Since amyloidβ containing senile plaques are characteristic in Alzheimer"s disease, DAPT may be useful in studies evaluating potential treatments for that disease.

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