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Human CD117 (c-kit) is a transmembrane protein with receptor tyrosine kinase capacity and serves as the receptor for steel factor (SLF). CD117 is expressed on almost all hematopoietic progenitor cells and receptor /ligand interaction is crucial for development of hematopoietic stem cells (2, 3).
Isotype: Murine IgG1
Immunogen: Human MO7e tumor cells
Specificity: Antibody 57A5 recognizes extracellular epitope 2 of the human CD117 molecule of about 150 kd.
Functional Application: Antibody 57A5 does not block binding of SCF (4).
References:
1. L.K. Ashman, et al, (1994) J Cellular Physiol 158: 545-554.
2. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 1856, 1882-1888.
3. J.R. Keller, et al, (1995) Blood 86: 1757-1764.
4. Leukocyte Typing VI (T. Kishimoto, et al, eds.) Garland Publishing, Inc., New York (1997) p. 816-818.
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