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echelon-inc/Geranylgeranyl Diphosphate (GGPP)/10mg/I-0200-10mg


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CatalogNo.: I-0200
MW: 501.53
CAS: 104715-21-1

Description: Isoprenoidcompoundsareadiversegroupofnaturalproductswhichareessentialcomponentsinallcells.Isoprenoidsarebiosynthesizedfromthesimpleprecursorsisopentenyldiphosphate(IPP)anddimethylallyldiphosphate(DMAPP).Eukaryotes,fungi,andsomegram-positivebacteriaproduceIPPthroughthemevalonate(MVA)pathwaywhereasgram-negativeandsomegram-positivebacteriautilizethenon-mevalonateor2-C-methyl-D-erythritol-4-phosphate(MEP)pathway.

Providedasthetris-ammoniumsalt

Storage

-20°Corbelow.

featuredinPublications

1)Gibot,L.,J.Follet,etal.(2009)."Humancaspase7ispositivelycontrolledbySREBP-1andSREBP-2."BiochemJ420(3):473-83.
2)Lai,D.,B.Lluncor,etal.(2009)."ReconstructionofthearchaealisoprenoidetherlipidbiosynthesispathwayinEscherichiacolithroughdigeranylgeranylglycerylphosphate."MetabolicEngineering11(3):184.
3)Zhou,X.-P.,K.-Y.Wu,etal.(2008)."TrkB-mediatedactivationofgeranylgeranyltransferaseIpromotesdendriticmorphogenesis."ProceedingsoftheNationalAcademyofSciences105(44):17181-17186.
4)Gruenbacher,G.,H.Gander,etal.(2010)."IL-2costimulationenablesstatin-mediatedactivationofhumanNKcells,preferentiallythroughamechanisminvolvingCD56+dendriticcells."CancerRes70(23):9611-20.

ProductKeywords:Geranylgeranylpyrophosphate,GGPP

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