CatalogNo.: F-H050 MW: 562.66 CAS: 553-12-8 Description: ProtoporphyrinIXisanintermediateintheHemesynthesispathwayandisformedfromProtoporphyrinogenIIIinareactioncatalyzedbytheenzymeProtoporphyrinIIIoxidase.IronintheferrousstateisaddedtoProtoporphyrinIXtoformhemeinareactioncatalyzedbytheenzymeferRochelatase.ProtoporphyrinIXhasbeenfoundtoactivateguanylatecyclaseandhasbeenfoundtoinduceapoptosisinHeLacells. | |||
StorageProtoporphyrinIXisstableforatleastoneyearwhenstoredasasolid,protectedfrommoisture,at-20°C.Protectfromlight.References1)Ignarro,L.M.,KSWood,andMSWolin.(1982)ActivationofpurifiedsolubleguanylatecyclasebyprotoporphyrinIX.ProcNatlAcadSciUSA.May;79(9):2870–2873.2)Bednarz,N.,J.Zawacka-Pankau,etal.(2007)."ProtoporphyrinIXinducesapoptosisinHeLacellspriortophotodynamictreatment."PharmacolRep59(4):474-9 3)Strand,A.,T.Asami,etal.(2003)."ChloroplasttonucleuscommunicationtriggeredbyaccumulationofMg-protoporphyrinIX."Nature421(6918):79. |
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