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echelon-inc/Protoporphyrin IX/1g/F-H050-1g


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CatalogNo.: F-H050
MW: 562.66
CAS: 553-12-8

Description: ProtoporphyrinIXisanintermediateintheHemesynthesispathwayandisformedfromProtoporphyrinogenIIIinareactioncatalyzedbytheenzymeProtoporphyrinIIIoxidase.IronintheferrousstateisaddedtoProtoporphyrinIXtoformhemeinareactioncatalyzedbytheenzymeferRochelatase.ProtoporphyrinIXhasbeenfoundtoactivateguanylatecyclaseandhasbeenfoundtoinduceapoptosisinHeLacells.

Storage

ProtoporphyrinIXisstableforatleastoneyearwhenstoredasasolid,protectedfrommoisture,at-20°C.Protectfromlight.

References

1)Ignarro,L.M.,KSWood,andMSWolin.(1982)ActivationofpurifiedsolubleguanylatecyclasebyprotoporphyrinIX.ProcNatlAcadSciUSA.May;79(9):2870–2873.
2)
Bednarz,N.,J.Zawacka-Pankau,etal.(2007)."ProtoporphyrinIXinducesapoptosisinHeLacellspriortophotodynamictreatment."PharmacolRep59(4):474-9
3)Strand,A.,T.Asami,etal.(2003)."ChloroplasttonucleuscommunicationtriggeredbyaccumulationofMg-protoporphyrinIX."Nature421(6918):79.

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