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echelon-inc/Biotinylated Anti-PtdIns(4,5)P2 IgM/250ug/Z-B045-250ug

 
CatalogNo.: Z-B045

Description: PurifiedAnti-PtdIns(4,5)P2monoclonalantibodyconjugatedwithbiotin.
Subclass:IgM
Source:Mouse
Applications:ELISA,Immunofluorescence,Protein-LipidOverlay(PIPStrip)

ProductBackground:Phosphoinositides(PIPns)areminorcomponentsofcellularmembranesbutareintegralsignalingmoleculesforcellularcommunication.Phosphatidylinositol4,5-bisphosphate(PIP2)hasbeenshowntoplayacentralroleinavarietyofcellularfunctions.Amongstitsmanyfunctions,PIP2isasubstrateforPhospholipaseC-coupledG-proteinpathwaysinvolvedinintracellularcalciumreleaseinanumberoftissues.ItisalsoasubstrateforclassIphosphoinositide3-kinase(PI3-K)formingPIP3.

Storage

2-8°Cforupto30days,-20°Cforgreaterthan30days.Donotfreezethawmultipletimes

FeaturedinPublications

1)Hoek,K.L.,P.Antony,etal.(2006)."TransitionalBcellfateisassociatedwithdevelopmentalstage-specificregulationofdiacylglycerolandcalciumsignalinguponBcellreceptorengagement."JImmunol177(8):5405-13.
2)Antony,P.,K.Hoek,etal.(2007)."Micro-scaleflowcytometry-basedandbiochemicalanalysisoflipidsignalinginprimaryBcellsubpopulations."BiolProcedOnline9:73-83.
3)Marquez,M.G.,C.Fernandez-TomeMdel,etal.(2009)."Bradykinininducesformationofvesicle-likestructurescontainingvinculinandPtdIns(4,5)P2inrenalpapillarycollectingductcells."AmJPhysiolRenalPhysiol297(5):F1181-91.

RelatedProducts

PurifiedAnti-PtdIns(4,5)P2IgM(Z-P045)
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Anti-PtdIns(4,5)P2IgMInAscites(Z-A045)
FluoresceinconjugatedAnti-PI(4,5)P2IgM(Z-G045)
Anti-PtdIns(4,5)P2IgMHRP(Z-H045)

Productkeywords:PIP2,PI(4,5)P2,PtdIns(4,5)P2,IgM,anti-PIP2

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