产品资料

Immunoway/CARD11 (phospho-Ser652) rabbit pAb/20ug 50ug 100ug/YP1286

CARD11 (phospho-Ser652) rabbit pAb

Specificity：
This antibody detects endogenous levels ofHuman Mouse Rat CARD11 (phospho-Ser652)

Purification：
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Other Name：
Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 1) (Carma 1)

Background：
caspase recruitment domain family member 11(CARD11) Homo sapiensThe protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008],

Function：
caution:Supposed to contain a SH3 domain which is not detected by PROSITE, Pfam or SMART.,function:Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.,similarity:Contains 1 CARD domain.,similarity:Contains 1 guanylate kinase-like domain.,similarity:Contains 1 PDZ (DHR) domain.,subunit:CARD11 and BCL10 bind to each other by CARD-CARD interaction.,tissue specificity:Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL-60 cells, chronic myelogenous leukemia K562 cells, Burkitt"s lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in HeLa S3, Molt-4, A549 and G431 cells.,

Subcellular Location：
immunological synapse,cytoplasm,cytosol,plasma membrane,T cell receptor complex,membrane raft,extracellular exosome,