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Clone GMA-070
Background
Factor XI is a key player in the intrinsic blood coagulation pathway.It circulates in complex with high molecular weight kininogen.When activated by factor XIIa, thrombin or autoactivation, the activated form factor XIa contributes to both hemostasis and thrombosis by amplifying thrombin generation and fibrin formation leading to clot formation.Human factor XI has a molecular weight of 160 kDa, and is comprised of a disulfide-linked dimer, with each monomer containing four apple domains that form a ring around the base of the catalytic domain. GMA-070 (also known as 5F71) is suitable for ELISA, western blot and immunopurification1 applications.
More Information
Product Datasheet as PDF
Description
- Species Reactivity:Human
- Source:Murine
- Specificity:Factor XI
- Immunogen:Human Factor XI
- Isotype:IgG1
Application
- ELISA:Binds human factor XI and human factor XIa.
- Immunoblotting:Western blot detects factor XI and factor XIa under non-reduced conditions.
Data
Antibody References
- Y. Su et al. (2011). J. Biol Chem. 286(36):31904-31914.
$265.00 – $660.00