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hypermol/Filamin (smooth muscle, turkey) - 2x100 µg/8312-01

Description

Filamin(Actin Binding Protein)Cat. #: 8312-01

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Description

Protein

Filamin (Filamin A)

Origin

Smooth muscle, turkey

Molecular mass

546kDa

Protein description

Filamin from turkey gizzard is a homodimer (2x273kDa) with a molecular mass of 546kDa, consisting of 24 repeats of ~96 amino acids and an N-terminal actin binding sequence. Filamin crosslinks actin filaments into orthogonal networks.The C-terminal end of each Filamin monomer is characterized by a hinge region, responsible for the flexibility of actin networks.

Actin interaction

Actin cross linking protein. Kd actin-binding = 0.5µM.

Properties

Form

Lyophilized, ready-to-use.

Quantity per unit

2x100µg

Buffer

10mMNaCl, 20mM Tris pH 7.4, 0.5mM DTT and 2.4% disaccharides, when reconstituted with 100 µlultrapure water to obtain a 1mg/ml solution.

Purity

>98%by scanning densitometryfrom Coomassie G-250 stained SDS-Gels.

Purification notes

Purified from turkey gizzard muscle.

Protein concentration

Determinedby OD280 (0.1%=0.64).

Storage instructions

Upon reconstitution the product is stored on ice. This product can also be stored as a glycerol stock at -20°C. Avoid repeated freeze / thaw cycles.

Shipping conditions

At ambient temperature. Upon delivery store at -70°C.

Remarks

For Use in Research only. Not for Use in Human or Veterinary Diagnostical or Therapeutical Applications.

CAS no.

Further Information

Product DataSheetMaterial and Safety Data SheetProtein Sequence on NCBI

ReferencesReal-timedynamicsofemergingactinnetworksincell-mimickingcompartments.Deshpande S, Pfohl T.; ​PLoS One. 2015 Mar 18;10(3):e0116521. doi: 10.1371/journal.pone.0116521. eCollection 2015.

A high molecular mass protein isolated from chicken gizzard: its localization at the dense plaques and dense bodies of smooth muscle and the Z-disks of skeletal muscle.Terasaki AG, Nakagawa H, Kotani E, Mori H, Ohashi K.,J Cell Sci. 1995 Mar;108 ( Pt 3):857-68

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