TransferrinisaglycoproteinwithhomologousN-terminalandC-terminaliron-bindingdomainsthatbindsuptotwoFe(III)atomsfordeliverytovertebratecellsthroughreceptor-mediatedendocytosis.Afterbindingtoitsreceptoronthecellsurface,transferrinisrapidlyinternalizedbyinvaginationofclathrin-coatedpitswithformationofendocyticvesicles,theacidicenvironmentfavorsdissociationofironfromthetransferrin-receptorcomplex.Followingthereleaseofiron,theapotransferrinisrecycledtotheplasmamembranewhereitisreleasedfromitsreceptortoscavengemoreiron.HumantransferrinislabeledwithourbrightandphotostableCF™dyesforinvestigationofendocytosisbymicroscopy.Downloadtheproductprotocoltoviewthefulllistofconjugatesandtheirexcitation/emissionwavelengths.
It’savailablewiththefollowingCF™dyes:CF488A,CF543,CF568,CF594,CF640R,CF680R,andCF750.
DownloadalistofCFdyereferences.
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