Product name | HUMAN MBL |
Cat-Nr. | TE323 |
Range | 0.41 to 100 ng/ml |
Sensitivity | 0.41 ng/mL (Detection limit) |
Incubation time | 4 hours |
Sample volume | 100 µl (diluted 1:50-1:100) |
Sample type | Precondition: Use polypropylene tubes Serum, plasma (heparin, citrate, not EDTA) Hemolyzed, hyperlipemic, heat-treated or contaminated samples may give erroneous results. |
Sample preparation | Store samples below -20°C, preferably at -70°C. Use samples within 24 hours after thawing. Avoid multiple freeze-thaw cycles |
Reference values | 10 to 5,000 ng/ml 12% of healthy Caucasian blood donors have MBL concentrations below 100 ng/ml. |
Species | Human |
Cross reaction | Cross-reactivity for other species or proteins/peptides has not been test |
Tests | 96 |
Method | ELISA |
Note | Interferences: This assay is designed to eliminate interference by soluble receptors, binding proteins, and other factors present in biological samples. |
Intended use | Mannose Binding Lectin (MBL) is a C-type lectin that is an important element in innate immunity. MBL is synthesized by hepatocytes and has been isolated from the liver or serum of several vertebrate species.It forms a complex with C1r/C1s like serine proteases designated MASP that proteolytically cleave C4, C2 and C3. MBL is able to activate the complement pathway independent of the classical and alternative complement activation pathways. The MBL-MASP pathway (better known as the lectin pathway) is antibody and C1q-independent. MBL exhibits complement-dependent anti-bacterial activity and acts directly as an opsonic and therefore plays an important role in innate immunity. Low plasma concentrations have been associated with an inherited defect in opsonization. The MBL concentration is enhanced in infectious diseases. Measuring of MBL is indicated in:
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Product informations | Kit Instructions (PDF 302,9 kB) Cross-reaction all species (PDF 70,3 kB) |
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