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| Product name | SC5b-9 Plus MicroVue™ Quidel®Quantification of the SC5b-9 complex  |
| Cat-Nr. | A029 |
| Range | 10 - 170 ng/ml |
| Sensitivity | LOD: 3.7 ng/ml; LLOQ: 8.8 ng/ml |
| Incubation time | 2 hours |
| Sample volume | 10 µl (dilute 1:40 for serum); 50 µl (dilute 1:10 for plasma) |
| Sample type | Serum, EDTA plasma, spinal fluid or other biological fluids |
| Sample preparation | The proper collection and storage of specimens is essential since SC5b-9 may be generated in improperly handled specimens. Serum or EDTA plasma specimens should be collected aseptically using standard techniques. They should be tested immediately or stored at 4 ºC or on ice until assayed. This should not exceed four hours. For longer-term storage freeze at -70 ºC. Plasma concentrations better reflect in vivo concentrations in comparison to serum concentrations. |
| Reference values | Serum 334 - 1672 ng/ml EDTA Plasma 127 - 303 ng/ml |
| Species | Human, cynomolgus macaque, baboon, rhesus macaque |
| Specificity | Monoclonal mouse-antibody, specifically binds SC5b-9. |
| Tests | 96 Tests |
| Method | ELISA |
| Intended use | The SC5b-9 enzyme immunoassay measures the amount of SC5b-9 present in human plasma, serum and other biological or experimental samples. The Terminal Complement Complex (TCC, SC5b-9) is generated by the assembly of C5 through C9 as a consequence of activation of the complement system by either the classical, lectin or alternative pathway. The membrane attack complex (MAC), a form of TCC, is a stable complex that mediates the irreversible target cell membrane damage associated with complement activation. |
| Product informations | Kit Instructions (PDF 672,3 kB) Cross-reaction all species (PDF 74,6 kB) Monitoring Complement Activation SC5b-9, C5a &CH50 (PDF 99,7 kB) Measurement of Complement Activation in Human Disease (PDF 4,6 MB) Hemocompatibility (PDF 6,4 MB) Information (PDF 680,3 kB) |
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