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Ion Biosciences/BRILLIANT THALLIUM FLEX/11000-10

ION Biosciences Brilliant Thallium Assay is a total assay solution for multi-well plate-based, high-throughput measurements of Tl+ flux through K+, Na+, non-selective cation channels, and some Na+ or K+ transporters. The ION Biosciences Brilliant Thallium Assay is also useful for a wide range of effectors of ion channels and transporters including G protein-coupled receptors, lipid and protein kinase, for example. In multi-well, plate-based formats, the Brilliant Thallium Assay can be used to discover and characterize the effects of tens to many tens-of-thousands of compounds and environmental factors on effectors of Tl+ flux. Over the past 15 years, fluorescence-based measures of Tl+ flux have been widely utilized to discovery small molecule modulators of a host of Ion channels, transporters, GPCRS and other targets of interest for both drug discovery and basic research.Inside the ION Brilliant Assay package, you will find all the reagents necessary for preparation of the Brilliant Thallium Assay for use as a washed or no wash assay for adherent and non-adherent cells. The addition of a probenecid solution and an extracellular background masking solution offers users the ultimate in compatibility for cells types which are difficult to load with fluorescent Tl+ indicators (e.g. Chinese Hamster Ovary, CHO cells) and when performing assays in complete, serum-containing cell culture medium is desired.About ION’s BRILLIANT THALLIUM MAVERICK , FLEX and EXPRESS Assay Kit

ION Biosciences’ Brilliant Thallium Assay series is a total assay solution for multi-well plate-based, high-throughput measurements of dynamic changes in Cell-based potassium ion channel screening. Ranging from the Maverick kit - you supply your own buffers, to the Flex kit – an assay kit Swiss Army Knife, to the Express kit - a premixed solution to rapidly facilitate your large-scale, high-throughput screening. Each assay kit is designed to be simple, fast, and reliable fluorescence-based assay. For years investigators have had only a choice between Molecular Devices’ FLIPR Potassium Assay Kit and FluxOR™ II Green Potassium Ion Channel Assay from Thermo Fisher as well (Thermo F10016, Thermo F10017, Thermo F10018, Thermo F10019). Whether your platform is FLIPR® or FlexStation®, FDSS, or Panoptic ION’s assay kits will provide a smooth process for your FLIPR® assay development and GPCR assays. There are no intermediate wash-steps required with these kits and you will find all the reagents necessary for preparation of the Brilliant Thallium Assay for use as a no wash assay or washed for adherent and non- adherent cells. Experienced screeners typically have a FLIPR® protocol they are familiar and comfortable with and ION’s high throughput thallium assay kits are optimized and streamlined to work seamlessly on Hamamatsu FDSS, FLIPR® Tetra Cellular Screening Systems used today. For investigators doing detection of potassium ion flux that prefer using a non-thallium based assay there is now a novel option: ION Potassium Green 2 (IPG-2) and ION Potassium Green 4 (IPG-4). Both indicators are available from ION Biosciences, LLC for potassium detection. Both novice and experienced users will enjoy large signal windows and the lowest lot-to-lot variability ensuring the highest quality, most consistent results. No-Wash Potassium Ion Channel Assay Evaluation kits are available by request at info@ionbiosciences.com

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Ion Biosciences/BRILLIANT THALLIUM FLEX/11000-10