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Abnova/ADAM17 (phospho T735) polyclonal antibody/1kit/PAB31643

  • Specification
  • Gene Info
  • Interactome
  • Pathway
  • Disease
  • Related Products
  • List All
  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of human ADAM17 (phospho T735).
  • Immunogen:
  • A synthetic peptide corresponding to amino acids 670-750 of human ADAM17 (phospho T735).
  • Host:
  • Rabbit
  • Reactivity:
  • Human, Mouse, Rat
  • Specificity:
  • This antibody detects endogenous levels of ADAM17 protein only when phosphorylated at T735.
  • Form:
  • Liquid
  • Purification:
  • Affinity purification
  • Isotype:
  • IgG
  • Recommend Usage:
  • ELISA (1:20000)Immunohistochemistry (1:100-300)Western Blot (1:500-2000)The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (50% glycerol, 0.5% BSA and 0.02% sodium azide).
  • Storage Instruction:
  • Store at -20°C.Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Datasheet:
  • PDF DownloadDownload
  • Applications
  • Western Blot
  • Immunohistochemistry
  • Enzyme-linked Immunoabsorbent Assay
  • Application Image
  • Western Blot
  • Immunohistochemistry
  • Enzyme-linked Immunoabsorbent Assay
  • Gene Information
  • Entrez GeneID:
  • 6868
  • Protein Accession#:
  • P78536
  • Gene Name:
  • ADAM17
  • Gene Alias:
  • CD156b,MGC71942,TACE,cSVP
  • Gene Description:
  • ADAM metallopeptidase domain 17
  • Omim ID:
  • 603639
  • Gene Ontology:
  • Hyperlink
  • Gene Summary:
  • This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq
  • Other Designations:
  • TNF-alpha converting enzyme,a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme),snake venom-like protease,tumor necrosis factor, alpha, converting enzyme
  • Interactome
  • Interactome
  • Gene Pathway
  • Alzheimer"s disease
  • Epithelial cell signaling in Helicobacter pylori infection
  • Notch signaling pathway
  • Related Disease
  • Alzheimer Disease
  • Arthritis, Rheumatoid
  • Breast cancer
  • Breast Neoplasms
  • Cardiovascular Diseases
  • Chronic Disease
  • Cleft Lip
  • Cleft Palate
  • Coronary Artery Disease
  • Crohn Disease
  • Crohn"s disease
  • Diabetes Mellitus
  • Diabetes Mellitus, Type 2
  • Edema
  • Genetic Predisposition to Disease
  • Lymphoma, Non-Hodgkin
  • Myocardial Infarction
  • Peripheral Vascular Diseases
  • Tobacco Use Disorder
      • ... see more
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