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Axon 3019
CAS [861038-72-4]
MF C15H19ClN2O.2HClMW 351.70
A2764 dihydrochloride is a selective inhibitor of TRESK (KCNK18) with an IC50 value of 11.8 μM. The degree of inhibition by 100 µM A2764 was larger in the activated state of TRESK than in the resting state of the channel. A2764 can inhibit TRESK in native cells, leading to cell depolarization and increased excitability.
KEYWORDS: A2764 dihydrochloride | supplier | TRESK inhibitor | A 2764 dihydrochloride | A-2764 dihydrochloride | CAS [861038-72-4] | [809248-52-0] | Potassium | TRESK | Inhibitor | Ion Channels | Migraine | Neuropathic pain | K2P18.1
| M Lengyel et al. Chemically Modified Derivatives of the Activator Compound Cloxyquin Exert Inhibitory Effect on TRESK (K2P18.1) Background Potassium Channel. Mol Pharmacol. 2019 Jun;95(6):652-660. |
2-(5-Chloroquinolin-8-yloxy)-N,N-diethylethanamine dihydrochloride
[809248-52-0]
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