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axonmedchem/EVP 4593/10 mg/Axon 2080

EVP 4593

Based on 18 reference(s) in Google Scholar91018

Axon 2080

CAS [545380-34-5]

MF C22H20N4OMW 356.42

  • Purity:99%
  • Soluble in DMSO

EVP 4593

Description

Potent NF-κB activation inhibitor (EC50: 9 nM); inhibits SOC pathway in HD neurons; exerts neuroprotective effects in transgenic HD flies and transgenic HD mouse neurons. EVP4593 was not active when tested in the IKK kinase assay
  • References
  • Certificates
  • Categories
  • Extra info
J Wu et al. Neuronal store-operated calcium entry pathway as a novel therapeutic target for Huntington"s disease treatment. Chem. Biol. 2011, 18(6), 777-793.
M Tobe et al. A novel structural class of potent inhibitors of NF-kappa B activation: structure-activity relationships and biological effects of 6-aminoquinazoline derivatives. Bioorg. Med. Chem. 2003, 11, 3869–3878.
  • Certificate of Analysis
  • Material Safety Data Sheet
CardiovascularCell Signaling & OncologyCNSImmunologyPain & InflammationTranscription FactorsNF-κBL-TypeNF-κB
NF-κB activation inhibitor; inhibits SOC pathway

Chemical name

N4-(4-phenoxyphenethyl)quinazoline-4,6-diamine

Parent CAS No.

[545380-34-5]

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