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axonmedchem/FDI 6 - NCGC 00099374/10 mg/Axon 2384

FDI 6 - NCGC 00099374

Based on 16 reference(s) in Google Scholar91016

Axon 2384

CAS [313380-27-7]

MF C19H11F4N3OS2MW 437.43

  • Purity:99%
  • Soluble in DMSO

FDI 6

Description

Inhibitor of the Forkhead box protein M1 transcription factor (IC50 value 22.5 µM for inhibiting FOXM1-DNA binding). FDI6 displaces ​FOXM1 from genomic targets in MCF-7 breast cancer cells, and induces concomitant transcriptional downregulation. FDI-6 is inactive against the proteasome, and concordance between its biophysical IC50 and cellular GI50 values (22.5 μM and 18.0 μM, respectively) suggests it does not suffer from the off-target effects of ​thiostrepton.
  • References
  • Certificates
  • Categories
  • Extra info
M.V. Gormally et al. Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition. Nat Commun. 2014 Nov 12;5:5165.
G. Marsico et al. Small molecule inhibition of FOXM1: How to bring a novel compound into genomic context. Genomics Data 3 (2015) 19-23.
  • Certificate of Analysis
  • Material Safety Data Sheet
Cell Cycle RegulationCell Signaling & OncologyEpigeneticsTranscription FactorsFOXM1TF class 3.3.1
Inhibitor of the Forkhead box protein M1 (FOXM1)

Chemical name

3-amino-N-(4-fluorophenyl)-6-(thiophen-2-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide

Parent CAS No.

[313380-27-7]

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