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axonmedchem/FQI 1/10 mg/Axon 2157

FQI 1

Based on 18 reference(s) in Google Scholar91018

Axon 2157

CAS [599151-35-6]

MF C18H17NO4MW 311.33

  • Purity:99%
  • Soluble in DMSO

FQI 1

Description

Antiproliferative small-molecule inhibitor of α-globin transcription factor CP2 (a.k.a. LSF; IC50 2.1 μM); cell-permeable, potent, specific, and reversible.FQI 1 induces cell death in LSF-overexpressing cells, including Hepatocellular carcinoma (HCC cells). FQI 1 inhibits LSF DNA-binding activity both in vitro and in vivo and also inhibits HCC tumor growth in a mouse xenograft model.
  • References
  • Certificates
  • Categories
  • Extra info
T.J. Granta et al. Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma. PNAS 2012, 109, 4503–4508.
H.C. Kang et al. Erythroid Cell-Specific α-Globin Gene Regulation by the CP2 Transcription Factor Family. Mol. Cell. Biol. 2005, 25, 6005–6020.
  • Certificate of Analysis
  • Material Safety Data Sheet
Cell Cycle RegulationCell Signaling & OncologyCNSImmunologyPain & InflammationCP2Transcription FactorsTF class 4
Inhibitor of α-globin transcription factor CP2 (LSF)

Chemical name

8-(2-ethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]quinolin-6(5H)-one

Parent CAS No.

[599151-35-6]

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