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axonmedchem/AMD 3100 - Plerixafor | SID 791 | JM 3100

AMD 3100 - Plerixafor | SID 791 | JM 3100

Based on 15 reference(s) in Google Scholar81015

Axon 1738

CAS [155148-31-5]

MF C28H54N8.8HClMW 794.47

  • Purity:100%
  • Soluble in water

AMD 3100

Description

Highly potent and selective chemokine CXCR4 receptor antagonist, with IC50 values to be 0.02-0.13 and >25 μM for CXCR4 and all other chemokine receptors respectively); HIV inhibitor; an immunostimulant used to multiply hematopoietic stem cells in cancer patients
E De Clercq et al. Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100. Antimicrob. agents chemother. 1994, 38(4), 668–74.
SL Davies et al. Plerixafor Hydrochloride. Drugs Fut. 2007,32(2), 123.
AF Cashen et al. AMD3100: CXCR4 antagonist and rapid stem cell-mobilizing agent. Future Oncol. 2007, 3(1), 19–27.
G Calandra et al. AMD3100 plus G-CSF can successfully mobilize CD34+ cells from non-Hodgkin"s lymphoma, Hodgkin"s disease and multiple myeloma patients previously failing mobilization with chemotherapy (...). Bone Marrow Transpl. 2008, 41, 331–338.
  • Certificate of Analysis
  • Material Safety Data Sheet
Cell Signaling & OncologyImmunologyStem CellImmunomodulatorA2Chemokine
CXCR4 antagonist

Chemical name

1,4-bis((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzene octahydrochloride

Parent CAS No.

[110078-46-1]

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