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| Alternative Name: | c-Jun N-terminal kinase 2, SAP kinase 1a, SAPK1a, MAP kinase 9, MAPK9 |
| Host: | Rabbit |
| Immunogen: | Synthetic peptide corresponding to a portion of rat SAPKα. |
| UniProt ID: | P49186 |
| GenBank ID: | L27112 |
| Species reactivity: | Human, Mouse, Rat |
| Applications: | ELISA, WB |
| Recommended Dilutions/Conditions: | Western Blot (1:500) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Formulation: | Liquid. Whole rabbit serum. |
| Handling: | Avoid freeze/thaw cycles. |
| Shipping: | Shipped on Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | The Stress-activated protein kinases alpha and gamma (SAPKalpha and gamma), also know as c-Jun NH2-terminal kinases 1 and 2 (Jnk1/2) are serine/ threonine protein kinases belonging to the MAP kinase family. The extracellular stimuli leading to cell stress include inflammatory cytokines (via Rho and Rac), growth factors, protein synthesis inhibitors and osmotic stress amongst others. Both Jnk1 and Jnk2 must be dually phosphorylated in the activation loop, at threonine 183 and tyrosine 185, to achieve full enzymatic activity. |
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