美国Pfenex公司总部在加利福尼亚的圣迭戈,是一家为生物制药和疫苗开发机构提供临床前cGMP级蛋白质的全球领先供应商。利用公司的核心技术——Pfēnex Expression Technology™在重组蛋白表达方面的应用,使Pfenex能够快速开发和生产高质量的蛋白和蛋白试剂。现Pfenex公司通过旗下的Reagent Proteins分部为全球药物研究和开发机构生产并销售相关蛋白产品。Pfēnex Expression Technology™核心专利技术结合了一个自动启用高通量平行菌株筛选技术,提供前所未有的能快速成功识别表达高可溶性滴度和活性蛋白的菌株。Pfenex公司已正式授权上海权阳贸易有限公司为中国地区首家且独家产品代理经销商。
Catalog Number
SEA-135
Description
Plasma protein from the blood of farmed S. salar
Product Background
Background:
- Fibrin gels made from salmon proteins have demonstrated remarkable properties in neuron survival and growth.
- Salmon fibrin gels represent the optimal matrix for neuronal cell cultural
- Salmon fibrin gels have also properties superior to mammalian gels in an in vitro angiogenesis model. The salmon gels were 60-188% more efficient than human fibrin gels supporting growth of human endothetlial cells. These results indicate that salmon fibrin may be attractive alternate ECM for support of microvascular network formation.
- Salmon fibrinogen and thrombin can be used at room temperature
- Soft salmon fibrin gels have been shown to promote selection and growth of tumorigenic cells
Research Targets:
- Regenerative Medicine
- Spinal Cord Injury
- Neural cell regrowth
- Pain & CNS Investigators
- Stem Cell Research
- Cancer stem cell research
Benefits:
- Superior Performance- demonstrated superiority to Matrigel as an extracellular matrix for neuronal cell growth.
- Safety from mammalian pathogens
- Easy of rehydration & improved thermal properties.
For more information on Salmon fibrinogen and thrombin:
Sieminski and Gooch. 2004. J Biomater Sci Polym. Ed 15(2):237-42
Ju, et al. Biomaterials. 2007 April; 28 (12): 2097-2108
Liu J, et al. Nat Mater. 2012 Jul 1;11(8):734-41. doi: 10.1038/nmat3361.
Information Sheet
Application Note
Category
Miscellaneous Proteins
Formulation
Dialyzed in 200 mM Tris, 3 mM CaCl2, 0.15M NaCl, pH 7.2-7.5.
Reconstitution
Rehydrate with H2O at room temperature or below. Remove the amount to be used that day, and hold on ice. Salmon thrombin retains greater than 80% activity after 24 hours on ice. Aliquot remaining thrombin and freeze at <-60°C
Storage
Freezer (<-10°C). Avoid freeze-thaw cycles
Purity
Affinity chromatography on immobilized heparin, SDS-PAGE
Sourced from salmon shown by certified tests to be negative for fish viruses. Activity tested by spectrophometric analysis of peptide hydrolysis (Chromozyme), and compared to human standard.
Filtered to 0.2 u
Activity
≥ 1000 Units/ mg protein
References
US Patent #6,007,811 and 6,861,225. Michaud et al, 2002. Thrombosis Research 107:245-54
Sieminski and Gooch. 2004. J Biomater Sci Polym. Ed 15(2):237-42
Ju, et al. Biomaterials. 2007 April; 28 (12): 2097-2108
Salmon fibrin treatment of spinal cord injury promotes functional recovery and density of serotonergic innervation
Liu J, et al. Nat Mater. 2012 Jul 1;11(8):734-41. doi: 10.1038/nmat3361.
Reagent Proteins is the Source for proteins.
From custom protein production to our over 5,000 catalog proteins, we are a leading supplier of reagent, pre-clinical and cGMP grade proteins to the biopharmaceutical and vaccine development community. We ensure the cost-effective and rapid delivery of high quality recombinant proteins to enable your research and development efforts.
为满足集团公司优质客户的广泛生物材料使用需求,公司长期以来提供国际小众品牌的代采购增值服务。经过多年的经验积累和客户反馈,已经建立了成熟完善的国际采购业务平台,美东美西两大合作集货点,自有快速审批和进出口通道。现将此服务开放给广大经销商合作伙伴和全国科研工作者,致力于缩短中国与国际一线研发的差距。
A: AB Biosciences 、ABP Biosciences、aldevron、Almac、Altogen Biosystems americanBIO、Amsbio、ANP Technologies、Antibody Solutions、Arrayit、ARENA CHEMICAL、A.COSTANTINO
B:Bel-Art、BGSC、Brooklyn Tool 、Biomatrica、Biopredic、BioControl、BioGenes
C:C Technologies、Central Drug House(P) Ltd、ChemScence、CHEMTRADE、CompTech、Coriell Institute、Creative Biolabs、Computype、Craic
D:D&M continuous、DiAgam、Diamond Materials、DocuSign、Dravon、Desert King
E:EdgeBio、EMC microcollections、ENVAIR、EXCEL Scientific、EMC microcollections
F:Faucet Queen、FinaBio
G:G&P Biosciences、Globe、GLO GERM、glycosynth
H:hellobio、HENKE-SASS WOLF、Higgins Analytical、HJ-BIOANALYTIK
I:Ivy Fine Chemicals、Invitek、Inycom Biotech、iQBIOSCIENCES
J:JCRB Cell Bank、
K:Kerafast、KOAMTAC
L:LAB BIO、LC Labs、LigaTrap、Lighthouse data、LP ITALIANA、Lumafluor、LYTIC SOLUTIONS
M:Medkoo、Maddak、MIMETAS、MiTeGen
N:Neuro Prob、NextGene、nippongenetics、NORTHWEST ANALYTICS、NovaBioAssays、NU-CHEK PREP
O:Orbital Biosciences 、OXITENO
P:PAR、PyMOL、Pharmaffiliates、Panagene、Pel Freez、PFEnex、Polylc、Proliant Biologicals
R:Riken、RANKIN、Ratiolab
S:SRL、SPD Scientific、Sanquin、Sbio、Scarab Genomics、Simport、SOVICELL、Starna cells
T:TSC、Tower optical corporation、TwistDx、TEKnova、Transposagen、Tribioscience、TriLink
U:Ultivue
X:ximbio
Z:Zymesci
细胞:Riken、JCRB Cell Bank、Kerafast、
软件:DocuSign、GraphPad、PyMOL、Craic、NextGene、Lighthouse data
(此处以Amsbio为例,实际不同品牌不同产品类型所涉及流程稍有不同)
1. 本公司并非以上各个品牌在中国区代理商,仅提供产品代理采购业务。
2. 本公司承诺所采购产品来自品牌厂家,并可提供相关进口证明。
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依托于集团公司深厚的资源和超过400家国内优质客户群体,生命科学领域一站式供应链体系,以及高风险生物材料进出口平台的优势,蚂蚁淘生物严格筛选国际创新且经过同行验证过的产品和技术,引入中国市场,开发、孵育和推广。
自公司成立以来,与海外一线品牌建立了长期的交流与合作关系,其中包括多家国际著名细胞和菌种保藏中心。仅2019年内,蚂蚁淘生物接受国内制药企业、科研机构、检测机构和大专院校等单位的委托,从近150个品牌引进各类生物试剂,其中不乏包括细胞株 ,慢病毒,人体组织切片,血液制品等特种试剂。公司与北京中关村联合创新(绿通北平台)建立了长期的交流与合作关系,可为国内客户提供进口代理业务,完成一站式前置审批、风险评估、检疫审批、清关查验、物流仓储等工作。
本公司特殊物品进口业务,严格遵守国家相关政策和法规流程,致力于为各单位提供更安全、更专业、更便捷的服务。