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MACS(美天旎)/CD209 (DC-SIGN) antibodies, human/for 30 tests/130-099-977

CloneDCN47.5recognizesCD209(DendriticCellSpecificICAM-3GrabbingNon-integrin,DC-SIGN),atypeIIc-typelectinexpressedindermalandmucoustissue,lymphoidtissuesuchastonsil,lymphnode,spleen,andonmonocyte-derivedDCs(MoDCs).ItisnotexpressedonDCsubsetsinperipheralblood,exceptforasubpopulationofCD14
+
cellswithaDC-likephenotype.
DC-SIGNactsasanadhesionreceptortofacilitateinteractionsbetweenDCsandTcellsorDCsandendothelialcells.Inaddition,itservesasanantigenreceptormediatinginternalizationofligandsforantigenpresentation,bindingvirussuchasHIV,HCMV,orEbolaaswellasparasites,bacteria,oryeast.
HIV-1usesthisfeatureofDC-SIGNforefficientin
-trans
infectionofCD4
+
Tcells.

Alternativenames

CDSIGN,CLEC4L,DC-SIGN
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